Dr. Xuegeng Wang


Dr. Xuegeng Wang
Postdoctoral Research Fellow

Contact
x_wang24@uncg.edu
336-450-8854
106 Eberhart Building

 

Education & Training
Ph.D. (2017). Peking University
Postdoctoral Training (2017~ present). University of North Carolina Greensboro

Research
Environmental stressors can establish epigenetic memories in the primordial germ cells that are precursors of eggs and sperm. Environmentally established epigenetic memories may escape epigenetic reprogramming during early embryogenesis and sex determination and maintain permanent profile leading to various reproductive and non-reproductive diseases in the offspring across several generations. My research focus is to dissect phenotypes and their genome-wide epigenetic association in medaka fish exposed to environmental stressors.

Recent Publications

  1. Jiang L., Zhang J., Wang J.J., Wang L., Zhang L., Li G., Yang X., Ma X., Sun X., Cai J., Zhang J., Huang X., Yu M., Wang X., Liu F., Wu C., He C., Zhang B., Ci W., Liu J. Sperm, but Not Oocyte, DNA methylome is inherited by zebrafish early embryos. Cell, 153:773-784. [PMID: 22663777]
  2. Wang, X., Zhu, Z., Sun, Y., Zhao J. 2013. Nuclear transfer and reprogramming in fish. Hereditas (Beijing), 35(4), 433-440. (Review) [PMID: 23659953]
  3. Wang,, Bhandari, R.K. (2019). DNA methylation dynamics during epigenetic reprogramming of medaka embryo. Epigenetics. 14(6):611-622. [PMID: 31010368]
  4. Wang, X.Hill, D., Tillitt, D.E., Bhandari, R.K. (2019). Bisphenol A and 17alpha-ethinylestradiol induced transgenerational differences in expression of osmoregulatory genes in the gill of medaka (Oryzias latipes). Aquatic Toxicology. 211: 227-234. [PMID: 31048106]
  5. ‡Wang, X., Bhandari, R.K.(2020 ). The Dynamics of DNA methylation during epigenetic reprogramming of primordial germ cells in medaka (Oryzias latipes), Epigenetics 15: 483-498 [PMID: 31851575]
  6. ‡Wang, X., Bhandari, R.K. (2020 ). DNA methylation reprogramming in medaka fish, a promising animal model for environmental epigenetics research. Environmental Epigenetics.6(1):dvaa008.<a
  7. Thayil, A.J., ‡Wang, X., Bhandari, P., vom Saal, F.S., Tillitt, D.E., Bhandari, R.K. (2020). Bisphenol A and 17 alpha-ethinylestradiol-induced Transgenerational Gene Expression Differences in the Brain-Pituitary-Testis Axis of Medaka, Oryzias latipes. Biology of Reproduction. [in press]
  8. Song, X., Wang, X., Bhandari, R.K. (2020). Developmental abnormalities and epigenetic effects in medaka (Oryzias latipes) embryo induced by triclosan exposure. Chemosphere. (In press)
  9. Bhandari, R.K., ‡Wang, X., vom Saal, F.S., Tillitt, D.E. (2020). Transcriptome analysis of testis reveals the effects of developmental exposure to bisphenol A or 17α-ethinylestradiol in medaka. Aquatic Toxicology. [In press]
  10. Bhandari, R.K., Wang, X.,vom Saal, F.S., Tillitt, D.E. Transgenerational effects of environmental chemicals on fish.
  11. Song, X.,  Wang, X.,Bhandari, R.K. MicroRNA expression during maternal to zygotic genome activation in medaka (Oryzias latipes). Submitted
  12. Wang, X., Tillitt, D.E., Vom Saal, F.S., Bhandari, R.K. (2021). Epigenomewide comparison reveals an escape and inheritance of differential DNA methylation memories in germline cells and soma across generations. (In preparation)
  13. Wang X.,Song, X., Bhandari, R.K. miRNA expression dynamics during epigenetic reprogramming of primordial germ cells. In preparation
  14. Wang, X., Bhandari, R.K., Methylome profile of medaka sperm and egg. In preparation 
  15. Wang, X., Bhandari, R.K., Environmental chemical induced single nucleotide polymorphism in germ cells and sperm. In preparation
  16. Bhandari, R.K., Wang, X., vom Saal, F.S., Tillitt, D.E.  Transgenerational inheritance of environmentally induced DNA methylation patterns in primordial germ cells by testicular somatic cells. In preparation
  17. Killian, D., Canipe, T., Carr, G., Feist, D., Kibobi, H., McNeely, E., Parker, L., Paul, M., Uyadi, S., Wang, X., Bhandari, R.K.. Embryonic development in fish is hindered by exposure to environmentally relevant concentrations of glyphosate. In preparation
  18. Feng, Y., Wang, X., Vassall, M., Bhandari, R.K. Delta-9-tetrahydrocannabinol-induced transcriptional alterations in the brain, liver, and testis of medaka fish. In preparation
  19. **Fricault, F.J., Wang, X., Aravamudhan, S., Bhandari, R.K. Effects of aluminum oxide and cerium oxide nanoparticles on human lung alveolar cells in vitro. In preparation
  20. Wang X.*, Zhao Y.*, Tian, T., Zhu, Z. Luo, J., Zhao, J. Genome-wide DNA methylation analysis of somatic cell nuclear transfer (SCNT) zebrafish embryos. (In preparation, *co-first author).
  21. Zhao Y.*, Wang X.*, Zhu,Z., Luo, J., Zhao, J. The DNA methylation landscape of zebrafish embryos during blastula-gastrulation transition. (In preparation, *co-first author).

Presentations

  1. *Wang, X., Bhandari, R.K. Global genome methylation changes during early embryonic development in medaka, Oryzias latipes. 77th Annual Meeting of the Society for Developmental Biology. Portland, OR. July 20-24, 2018.
  2. *Bhandari, R.K., Wang, X., Cleary, J.A., vom Saal, F.S., Tillitt, D.E. Somatic inheritance of transgenerational germline epigenetic marks in the medaka fish testis. 77th Annual Meeting of the Society for Developmental Biology. Portland, OR. July 20-24, 2018.
  3. *Wang, X., Bhandari, R.K. Epigenetic programming of medaka embryo. 9th Aquatic Models of Human Disease Conference. Marine Biology Laboratory, Woods Hole, MA. September 29-October 4, 2018.
  4. *Bhandari, R.K., Wang, X., Cleary, J.A., vom Saal, F.S., Tillitt, D.E.  Medaka as a model for studying transgenerational inheritance of phenotypes and underlying mechanisms.39th Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC). Sacramento, CA. 11/04-07, 2018.
  5. *Wang, X., Hill, D., Tillitt, DE, Bhandari, RK. Environmental estrogen-induced transgenerational differences in expression of osmoregulatory genes in the gill of medaka fish. Biannial Meeting of the North American Society for Comparative Endocrinology (NASCE). May 23-27, 2019.
  6. *Bhandari, R.K., Wang, X., vom Saal, F.S., Tillitt, D.E. Reprogramming of BPA-induced alterations in primordial germ cells and transgenerational inheritance of reproductive and developmental phenotypes in medaka. 20th International Symposium on  Pollutant Responses in Marine Organisms(PRIMO20), Charleston, SC USA. May 19 – May 22, 2019.
  7. Wang, X., Bhandari, R.K. 40th Annual Meeting of the Society of Environmental Toxicology and Chemistry. Dynamics of environmentally induced DNA methylation signatures in germ cells. 40th Annual Meeting of the Society of Environmental Toxicology and Chemistry, Toronto, Canada. November 3-7, 2019.
  8. Wang, X. (2020). Epigenetic Inheritance and Environmental Health Effects. Department of Biology Seminar Series, Spring 2020. University of North Carolina Greensboro. (Invited)