Epigenetic changes control the way genetic information is expressed without altering genetic codes stored in DNA. Environmental exposures can induce epigenetic changes, but the extent of epigenetic damage depends on life history stages of the organism exposed. Our laboratory is trying to understand how environmental stressors (chemical or non-chemical) can induce epigenetic changes that result in adverse health outcomes or disease. Utilizing animal models (fish and rodents), cell co-cultures (normal cells and organoids), human tissue samples, and population-based studies, we are trying to pinpoint how epigenetic changes lead to harmful health effects, which could perhaps be passed on to future generations. Research is no FUN without “D” in it, so we are seeking research FUNDS (US federal and/or private foundations) to identify epigenetic biomarkers that may explain past exposures and predict future diseases.
Current projects include basic science of germ cell epigenetic programming and epigenotoxicity of environmental stressors such as, pharmaceuticals, pesticides, bisphenol A, bisphenol S, fire retardants, marijuana (including its metabolites), and engineered nanoparticles in germ cells.
Interested in research?
Our laboratory is seeking several graduate students (MS) to participate in environmental epigenetics and transgenerational health research. Undergraduate students (preferably sophomores and juniors) can register for Bio-499 research credit. All interested persons should contact Dr. Ramji Bhandari () for further details. If you are a potential graduate (Ph.D.) student and would like to apply for a fellowship through philanthropic foundations, NSF or NIH, please contact me ahead of time, so we can discuss about the project.
Dr. Bhandari will chair an epigenetic session at the 39th Annual Meeting of the Society of Environmental Toxicology and Chemistry which is going…
Dr. Xuegeng Wang will give a talk at the 9th Aquatic Models for Human Diseases conference which is going to be held…
The Bhandari Lab will present research papers at the Meeting of Developmental Biologists in Portland, OR in July, 2018. Dr. Xuegeng Wang…
The Bhandari Lab will present a paper at Society of Reproduction meeting at New Orleans, LA in July 2018. http://www.ssr.org/18Meeting
Dr. Bhandari will be co-chairing a session “Characterization of Mechanisms and Potential Toxicity for New and Emerging EEDs” with Dr. Stephen Ferguson…
- Bhandari Research Group
- Department of Biology
- University of North Carolina at Greensboro
- 114 Eberhart Bldg, 321 McIVer St
Greensboro, NC 27402-6170
- Phone: 336.256.0493