Environmental Epigenetics

Epigenetic changes control the way genetic information is expressed without altering genetic codes stored in DNA. Environmental exposures can induce epigenetic changes, but the extent of epigenetic damage depends on life history stages of the organism exposed. Our laboratory is trying to understand how environmental stressors (chemical or non-chemical) can induce epigenetic changes that result in adverse health outcomes or disease. Utilizing animal models (fish and rodents), cell co-cultures (normal cells and organoids), human tissue samples, and population-based studies, we are trying to pinpoint how epigenetic changes lead to harmful health effects, which could perhaps be passed on to future generations. Research is no FUN without “D” in it, so we are seeking research FUNDS (US federal and/or private foundations) to identify epigenetic biomarkers that may explain past exposures and predict future diseases.

Current projects include basic science of germ cell epigenetic programming and epigenotoxicity of environmental stressors such as, pharmaceuticals, pesticides, bisphenol A, bisphenol S, fire retardants, marijuana (including its metabolites), and engineered nanoparticles in germ cells.

 

Interested in research?

Our laboratory is seeking graduate students (MS and PhD) to participate in environmental epigenetics and transgenerational health research. Undergraduate students (sophomores and juniors) can register for Bio-499 research credit. All interested persons should contact Dr. Ramji Bhandari (for further details.  If you are a potential graduate (Ph.D.) student and would like to apply for a fellowship through philanthropic foundations, NSF or NIH, please contact me ahead of time.

Recent News

A manuscript accepted for publication!

Chelsea’s manuscript entitled “Developmental and epigenetic effects of Roundup and glyphosate exposure on medaka (Oryzias latipes) has been accepted for publication in…


Research presented at Triangle Consortium for Reproductive Biology (TCRB)

Research from the Bhandari Lab was presented at Triangle Consortium for Reproductive Biology (TCRB) held at National Institute of Environmental Health Sciences…


Xiaohong Song completed her stay at Bhandari Lab

Xiaohong Song, a visiting graduate student from the College of Environmental Science and Engineering, Guilin University of Technology, Guilin, China, completed her…


Valerie Fricault graduated!!!

Valerie defended her thesis on November 16th and graduated on December 07, 2018. Her graduate thesis is entitled “Effects of Exposure to…


The Bhandari Lab in a research magazine

The Bhandari lab got a media coverage recently. Here are a few links: Department of Biology News   UNCG Research Magazine  Pdf of the…


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Contact Us

Bhandari Research Group
Department of Biology
University of North Carolina at Greensboro
114 Eberhart Bldg, 321 McIVer St
Greensboro, NC 27402-6170
Phone: 336.256.0493
"Our lab is a part of Environmental Health Sciences Graduate Program at the UNCG Department of Biology. Our graduate students have opportunities to specialize in a wide ranges of topics from ecosystem health to transgenerational organismal health "