Epigenetic changes control the way genetic information is expressed without altering genetic codes stored in DNA. Environmental exposures can induce epigenetic changes, but the extent of epigenetic damage depends on life history stages of the organism exposed. Our laboratory is trying to understand how environmental stressors (chemical or non-chemical) can induce epigenetic changes that result in adverse health outcomes or disease. Utilizing animal models (fish and rodents), cell co-cultures (normal cells and organoids), human tissue samples, and population-based studies, we are trying to pinpoint how epigenetic changes lead to harmful health effects, which could perhaps be passed on to future generations. Research is no FUN without “D” in it, so we are seeking research FUNDS (US federal and/or private foundations) to identify epigenetic biomarkers that may explain past exposures and predict future diseases.
Current projects include basic science of germ cell epigenetic programming and epigenotoxicity of environmental stressors such as, pharmaceuticals, pesticides, bisphenol A, bisphenol S, fire retardants, marijuana (including its metabolites), and engineered nanoparticles in germ cells.
Interested in research?
Our laboratory is seeking graduate students (MS and PhD) to participate in environmental epigenetics and transgenerational health research. Undergraduate students (sophomores and juniors) can register for Bio-499 research credit. All interested persons should contact Dr. Ramji Bhandari () for further details. If you are a potential graduate (Ph.D.) student and would like to apply for a fellowship through philanthropic foundations, NSF or NIH, please contact me ahead of time.
Findings from Jacob Cleary’s masters project have been accepted for publication by Environmental Pollution Journal. We found a significant reduction in sperm…
Dr. Bhandari received a prestigious “Thomas Undergraduate Research Mentor Award” for the year 2019. This award is given to one faculty member…
Xuegeng’s paper entitled “Bisphenol A and 17alpha-ethinylestradiol induced transgenerational differences in expression of osmoregulatory genes in the gill of medaka fish (Oryzias…
Xuegeng’s manuscript entitled “DNA methylation dynamics during epigenetic reprogramming of medaka embryo” has been accepted for publication in Epigenetics. Congratulations, Xuegeng!!! Wang…
The Bhandari Lab presented three papers at the 2nd annual meeting of the Endocrine Disrupting Chemicals-North Carolina Society held at NIEHS, Research…
- Bhandari Research Group
- Department of Biology
- University of North Carolina at Greensboro
- 114 Eberhart Bldg, 321 McIVer St
Greensboro, NC 27402-6170
- Phone: 336.256.0493