Posted on March 6, 2017
The National Institute of Environmental Health Sciences has awarded Dr. Ramji Bhandari a R21 exploratory/developmental research grant to study germline transmission of epigenetic alterations to offspring induced by bisphenol A (BPA) exposure. The proposed study will identify unique epigenetic exposure profiles in germ cells that pass into offspring germ cells via eggs and/or sperm in the medaka fish. This information will provide new mechanistic insights into control mechanisms of transgenerational inheritance of abnormal traits and provides tools for development of diagnostic biomarkers for transgenerationally inherited diseases in humans.
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