February 15, 2023
Hosted By Dr. Zhenquan Jia
Vaporization and atmospheric release of per- and polyfluoroalkyl substances (PFAS) from industrial sources around the world have prompted the attention of communities in proximity to those industrial sources as well as the need to address our lack of understanding on consequences of pulmonary exposure to such chemicals. In this study, we investigated the effects of ammonium perfluoro(2-methly-3-oxahexanoate) (GenX), an emerging PFAS, on the pulmonary innate immune response of mice to carbon black nanoparticles (CBNP), a surrogate for ultrafine air pollution particles. Considering that PFAS are documented to be implicated in immune dysfunction observed in both experimental animals and humans, it was hypothesized that pulmonary exposure to GenX would exert immunomodulatory effects on the innate immune response to pulmonary exposure to CBNP.