Free radical toxicology; environmental cardiovascular inflammation and injury; redox signaling; amelioration of vascular dysfunction and toxicity with bioactive compounds.
Ph.D., Virginia Polytechnic Insitute and State University (Virginia Tech)
Research in my laboratory is focused on investigating environmental chemical-induced vascular inflammation and injury with a special interest on understanding the possible signaling mechanisms involved. The environmental chemicals of interest include the anthracycline quinone (known as doxorubicin), polycyclic aromatic hydrocarbon (PAH)-derived- quinones and acrolein. In line with this research, funded by the NIH, we are also actively investigating the molecular mechanism(s) of action of novel bioactive compounds that target and reduce toxicant-mediated cardiovascular inflammation. Our approaches include cell- and molecular biology techniques, and physiologically relevant animal models.
Jia Z, Nallasamy P, Liu D, Shah H, Li JZ, Chitrakar R, Si H, McCormick J, Zhu H, Zhen W, Li YR. Luteolin protects against vascular inflammation in mice and TNF-alpha-induced monocyte adhesion to endothelial cells via suppressing NF-ĸB signaling pathway, J Nutr Biochem, 26(3):293-302, 2015.
Speen A, Jones C, Patel R, Shah H, Nallasamy P, Brooke EA, Zhu H, Li YR, Jia Z. Mechanisms of CDDO-imidazolide-mediated cytoprotection against acrolein-induced neurocytotoxicity in SH-SY5Y cells and primary human astrocytes. Toxicol Lett. 238(1):32-42, 2015.
Shah H, Saunders C, Speen A, Brooke E, Nallasamy P, Zhu H, Li and Jia Z. Protection of HepG2 Cells from Acrolein Toxicity by CDDO-Im Via Glutathione-Mediated Mechanism. Exp Biol Med, 240(10):1340-51, 2015.
Chiu NHL, Jia Z, Diaz R, Wright P. Rapid Differentiation of In Vitro Cellular Responses to Toxic Chemicals by Using MALDI-TOF Mass Spectrometry. Environmental Toxicology and Chemistry, 34(1):161-6, 2015.
Li JZ, Ke Y, Misra HP, Trush MA, L YR, Zhu H, Jia Z. Mechanistic Studies of Cancer Cell Mitochondria- and NQO1-mediated Redox Activation of Beta-Lapachone, a Potentially Novel Anticancer Agent. Toxicology and Applied Pharmacology, 29;281(3):285-293, 2014.
Li YR , Zhu H, Kauffman M , Danelisen I, Misra HP, Ke Y, Jia Z. Paraoxonases Function as Unique Protectors against Cardiovascular Diseases and Diabetes: Updated Experimental and Clinical Data. Exp Biol Med, 5;239(8):899-906, 2014.
Nallasamy P, Si H, Babu PV, Fu Y, Brooke BS, Halley S, Zhen W, Zhu H, Liu D, Li Y, Jia Z. Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway. J Nutr Biochem, 25(8):824-33, 2014.
Wright PC, Qin H, Choi MMF, Chiu NH, Jia Z. Carbon nanodots interference with lactate dehydrogenase assay in human monocyte THP-1 cells. SpringerPlus, 3:615:1-5, 2014.
Fu Y, Luo J, Jia Z, Zhen W, Zhou K, Gilbert E, Liu D. Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice. Int J Endocrinol, 2014:846742, 2014.
Jia Z, Velayutham Anandh Babu P, Si H, Nallasamy P, Zhu H, Zhen W, Misra HP, Li Y, Liu D. Genistein prevents inhibits TNF-α-induced endothelial inflammation through the protein kinase A pathway and improves vascular inflammation in C57BL/6 mice. Int J Cardiol. 3;168(3):2637-45, 2013.
Jia, Z, Zhen, W, Babu, PV, Liu, D. Phytoestrogen genistein protects against endothelial barrier dysfunction in vascular endothelial cells through PKA-mediated suppression of RhoA signaling. Endocriology, 154(2):727-37, 2013.
Macrea MM, Martin T, Jia Z, Misra, HP. Leptin’s activity on the hydroxyl radical: a possible link to the oxidative stress-related endothelial vasodilation in patients with obstructive sleep apnea. Lung, 191:391–395, 2013.
Graham PM, Li JZ, Dou X, Zhu H, Misra HP, Jia Z, Li Y. Protection against peroxynitrite-induced DNA damage by mesalamine: implications for anti-inflammation and anti-cancer activity. Mol Cell Biochem, 378(1-2):291-8, 2013.
Jia Z., Zhu, H., Li, J., Wang, X., Misra, H., Y Li. Oxidative stress in spinal cord injury and antioxidant-based intervention. Spinal Cord, 50 (4), 264-74, 2012.
Si, H., Babu, P., Zhen, W., Leroith, T., Meaney, M., Voelker KA, Jia Z, Grange RW, Liu D. Dietary epicatechin promotes survival of obese diabetic mice and Drosophila melanogaster. J Nutr, 141 (6), 1095-100, 2011.
Zimmerman RP, Jia Z, Zhu H, Vandjelovic N, Misra HP, Wang J, Li Y. Induction of Oxidative DNA Damage by Mesalamine in the Presence of Copper: A Potential Mechanism for Mesalamine Anticancer Activity. Toxicology, 27; 280(3):71-6, 2011.
Environmental Health Science II (Bio-632)
Current Research in Environmental Health Science (BIO-634)
Molecular Toxicology (Bio-635)
Essentials of Toxicology (BIO-488)