Free radical toxicology; environmental cardiovascular inflammation and injury; redox signaling; amelioration of vascular dysfunction and toxicity with bioactive compounds.
Ph.D., Virginia Polytechnic Insitute and State University (Virginia Tech)
Research in my laboratory is focused on investigating environmental chemical-induced vascular inflammation and injury with a special interest on understanding the possible signaling mechanisms involved. The environmental chemicals of interest include the anthracycline quinone (known as doxorubicin), polycyclic aromatic hydrocarbon (PAH)-derived- quinones, acrolein, and nanoparticles. In line with this research, funded by the NIH, we are also actively investigating the molecular mechanism(s) of action of novel bioactive compounds that target and reduce toxicant-mediated cardiovascular inflammation. Our approaches include cell- and molecular biology techniques, and physiologically relevant animal models.
Shukla, H., R. Chitrakar, H. A. Bibi, G. Gaje, A. Koucheki, M. A. Trush, H. Zhu, Y. R. Li and Jia, Z (2020). “Reactive oxygen species production by BP-1,6-quinone and its effects on the endothelial dysfunction: Involvement of the mitochondria.” Toxicol Lett 322: 120-130
Liu, S., M. T. Tsui, E. Lee, J. Fowler and Jia, Z (2020). “Uptake, efflux, and toxicity of inorganic and methyl mercury in the endothelial cells (EA.hy926).” Sci Rep 10(1): 9023.
Shukla, H., G. Gaje, A. Koucheki, H. Y. Lee, X. Sun, M. A. Trush, H. Zhu, Y. R. Li and Jia, Z (2020). “NADPH-quinone oxidoreductase-1 mediates Benzo-[a]-pyrene-1,6-quinone-induced cytotoxicity and reactive oxygen species production in human EA.hy926 endothelial cells.” Toxicol Appl Pharmacol 404: 115180
Shukla, H., H. Y. Lee, A. Koucheki, H. A. Bibi, G. Gaje, X. Sun, H. Zhu, Y. R. Li and Jia, Z (2020). “Targeting glutathione with the triterpenoid CDDO-Im protects against benzo-a-pyrene-1,6-quinone-induced cytotoxicity in endothelial cells.” Mol Cell Biochem 474(1-2): 27-39
Ji, Z., Z. Yin, Jia, Z and J. Wei (2020). “Carbon Nanodots Derived from Urea and Citric Acid in Living Cells: Cellular Uptake and Antioxidation Effect.” Langmuir 36(29): 8632-8640.
Tian, S., J. Nakamura, S. Hiller, S. Simington, D. W. Holley, R. Mota, M. S. Willis, S. J. Bultman, J. C. Luft, J. M. DeSimone, Jia, Z, N. Maeda and X. Yi (2020). “New insights into immunomodulation via overexpressing lipoic acid synthase as a therapeutic potential to reduce atherosclerosis.” Vascul Pharmacol 133-134: 106777
Yi, X., Y. Wang, Jia, Z, S. Hiller, J. Nakamura, J. C. Luft, S. Tian and J. M. DeSimone (2020). “Retinoic Acid-Loaded Poly(lactic-co-glycolic acid) Nanoparticle Formulation of ApoB-100-Derived Peptide 210 Attenuates Atherosclerosis.” J Biomed Nanotechnol 16(4): 467-480 (Journal Impact Factor: 5.28).
Luo, J., Si, H., Jia, Z., Liu D (2021). “ Dietary anti-aging polyphenols and potential mechanisms.” Antioxidants (Basel) 10(2), 283 1-20
Bao, T.; Li, Y.; Xie, J.; Jia, Z.; Chen, W. Systematic evaluation of polyphenols composition and antioxidant activity of mulberry cultivars subjected to gastrointestinal digestion and gut microbiota fermentation. Journal of Functional Foods 58:338-349; 2019.
Petersen, C.; Wankhade, U. D.; Bharat, D.; Wong, K.; Mueller, J. E.; Chintapalli, S. V.; Piccolo, B. D.; Jalili, T.; Jia, Z.; Symons, J. D.; Shankar, K.; Anandh Babu, P. V. Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice. The Journal of nutritional biochemistry 66:63-69; 2019.
Sun, X.; Jia, Z. Microbiome modulates intestinal homeostasis against inflammatory diseases. Vet Immunol Immunopathol 205:97-105; 2018.
Yang, M.; Ahmed, H.; Wu, W.; Jiang, B.; Jia, Z. Cytotoxicity of Air Pollutant 9,10-Phenanthrenequinone: Role of Reactive Oxygen Species and Redox Signaling. BioMed research international 2018:9523968; 2018.
Karima, N, Jia, Z, Zheng X, Cui, S, Che W. A recent review of citrus flavanone naringenin on metabolic diseases and its potential sources for high yield-production. Trends in Food Science & Technology, 79, 35-54, 2018
Zhang, W., Chavez, J., Zeng, Z., Bloom, B.P., Sheardy, A., Ji, Z., Yin, Z., Waldeck, D.H., Jia, Z. and Wei, J.Antioxidant Capacity of Nitrogen, Sulfur Co-doped Carbon Nanodots. ACS Appl. Nano Mater. 2018, 1, 2699−2708, 2018.
Environmental Health Science II (Bio-632)
Current Research in Environmental Health Science (BIO-634)
Molecular Toxicology (Bio-635)
Essentials of Toxicology (BIO-488)
Current Topics in Biology (BIO 449)
Toxicological Research Laboratory (BIO 597)
Molecular Approaches to Research (Bio-482)