Postdoctoral Fellow Contact:
Dr. Ramji Bhandari
361 Eberhart Building
Ph.D., Peking University
Environmental stressors can establish epigenetic memories in the primordial germ cells that are precursors of eggs and sperm. Environmentally established epigenetic memories may escape epigenetic reprogramming during early embryogenesis and sex determination and maintain permanent profile leading to various reproductive and non-reproductive diseases in the offspring across several generations. My research focus is to dissect phenotypes and their genomewide epigenetic association in medaka fish exposed to environmental stressors.
Xuegeng Wang, Zuoyan Zhu, Yonghua Sun, Jue Zhao. 2013. Nuclear transfer and reprogramming in fish. Hereditas (Beijing), 35(4), 433-440. (Review)
Lan Jiang, Jing Zhang, Jing-Jing Wang, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang, Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci, Jiang Liu. 2013. Sperm, but Not Oocyte, DNA methylome is inherited by zebrafish early embryos. Cell, 153:773-784.