Ramji Bhandari

Ramji Bhandari

Assistant Professor
Bernard-Glickman Dean's Professor

(336) 256-0493
405 Eberhart Building


Gene Environment Interactions and Epigenetics


Ph.D., Hokkaido University


My research interests are to elucidate mechanisms underlying gene environment interactions and developmental origins of adult and transgenerational health abnormalities. My group takes comparative, molecular, cellular, and bioinformatics analysis approaches and utilizes cell/tissue culture and animal models (fish and rodents). Current projects include basic science of germ cell epigenetic programming, epigenotoxicity of environmental stressors such as: pharmaceuticals, pesticides, bisphenol A, marijuana (including its metabolites), engineered nanoparticles, etc., and trangenerational inheritance of  epimutations.


Recent Publications:

Wang. X., Bhandari. R.K. (2019). DNA methylation dynamics during epigenetic reprogramming of medaka embryo. Epigenetics. 1-10. [PMID: 31010368]

Wang, X., Hill, D., Tillitt, D.E., Bhandari, R.K. (2019). Bisphenol A and 17alpha-ethinylestradiol induced transgenerational differences in expression of osmoregulatory genes in the gill of medaka (Oryzias latipes). Aquatic Toxicology. 211: 227-234. [PMID: 31048106]

Cleary, J.C., Tillitt, D.E., vom Saal, F.S., Nicks, D.K., Claunch, R.A, Bhandari, R.K. (2019). Transgenerational effects of developmental Atrazine exposure on reproductive axis of medaka. Environmental Pollution, 251: 631-650. [PMID: 31108297]

Smith, C.S., Vera, M.K.M., Bhandari, R.K. (2019). Developmental and epigenetic effects of Roundup and glyphosate exposure on medaka (Oryzias latipes). Aquatic Toxicology, 210:215-226. [PMID: 30875550]

Bhandari, R.K., Taylor J.A., Sommerfield-Sager J., Tillitt D.E., Ricke W.A., Vom Saal F.S. (2019). Estrogen receptor 1 expression and methylation of Esr1 promoter in mouse fetal prostate mesenchymal cells induced by gestational exposure to bisphenol A or ethinylestradiol. Environmental Epigenetics. 5:dvz012 doi: 10.1093/eep/dvz012 [PMID: 31463084]

Bhandari, R.K. (2016). Medaka as a model for studying environmentally induced transgenerational inheritance phenotypes. Environmental Epigenetics 2:1-9.

Skinner, M.K., Bhandari, R.K., Haque, M.M., Nilsson, E.E. (2016). Environmentally induced epigenetic transgenerational inheritance of altered SRY genomic binding during gonadal sex determination. Environmental Epigenetics 1: 1-10. doi: 10.1093/eep/evv004

Bhandari R.K., vom Saal, F.S., Tillitt, D. E. (2015). Transgenerational effects from early developmental exposures to bisphenol A or 17α-ethinylestradiol in medaka, Oryzias latipes. Scientific Reports, 5 : 9303.

Bhandari RK, Deem SL, Holliday DK, Jandegian CM, Kassotis CD, Nagel SC, Tillitt DE, Vom Saal FS, Rosenfeld CS (2015). Effects of the environmental estrogenic contaminants bisphenol A and 17α-ethinylestradiol on sexual development and adult behaviors in aquatic wildlife species. General and Comparative Endocrinology. 214:195-219.

Skinner MK, Guerrero-Bosagna C, Haque M, Nilsson E, Bhandari RK, McCarrey JR (2013) Environmentally induced transgenerational epigenetic reprogramming of primordial germ cells and the subsequent germ line. PLoS One. 8(7):e66318.

Complete list of publications in google scholar


Developmental Biology (BIO 464)
Molecular Approaches to Research: Transgenerational Inheritance (Bio 596)
Human Embryology and Teratology (Bio 614)