Assistant Professor Contact:
Bernard-Glickman Dean's Professor
405 Eberhart Building
Gene Environment Interactions and Epigenetics
Ph.D., Hokkaido University
My research interests are to elucidate mechanisms underlying gene environment interactions and developmental origins of adult and transgenerational health abnormalities. My group takes comparative, molecular, cellular, and bioinformatics analysis approaches and utilizes cell/tissue culture and animal models (fish and rodents). Current projects include basic science of germ cell epigenetic programming, epigenotoxicity of environmental stressors such as: pharmaceuticals, pesticides, bisphenol A, marijuana (including its metabolites), engineered nanoparticles, etc., and trangenerational inheritance of epimutations.
Bhandari, R.K. (2016). Medaka as a model for studying environmentally induced transgenerational inheritance phenotypes. Environmental Epigenetics 2:1-9.
Skinner, M.K., Bhandari, R.K., Haque, M.M., Nilsson, E.E. (2016). Environmentally induced epigenetic transgenerational inheritance of altered SRY genomic binding during gonadal sex determination. Environmental Epigenetics 1: 1-10. doi: 10.1093/eep/evv004
Bhandari R.K., vom Saal, F.S., Tillitt, D. E. (2015). Transgenerational effects from early developmental exposures to bisphenol A or 17α-ethinylestradiol in medaka, Oryzias latipes. Scientific Reports, 5 : 9303.
Bhandari RK, Deem SL, Holliday DK, Jandegian CM, Kassotis CD, Nagel SC, Tillitt DE, Vom Saal FS, Rosenfeld CS (2015). Effects of the environmental estrogenic contaminants bisphenol A and 17α-ethinylestradiol on sexual development and adult behaviors in aquatic wildlife species. General and Comparative Endocrinology. 214:195-219.
Skinner MK, Guerrero-Bosagna C, Haque M, Nilsson E, Bhandari RK, McCarrey JR (2013) Environmentally induced transgenerational epigenetic reprogramming of primordial germ cells and the subsequent germ line. PLoS One. 8(7):e66318.
Developmental Biology (BIO 464)
Molecular Approaches to Research: Transgenerational Inheritance (Bio 596)
Human Embryology and Teratology (Bio 614)