Lara do Amaral Silva

Lara do Amaral Silva

Postdoctoral Fellow

Contact:
l_doamarals@uncg.edu
(336) 334-4991
365 Eberhart Building

Education

Ph.D., São Paulo State University, Brazil

Research:

My research focuses on identify physiological processes that transform brain function to maintain performance during oxygen deprivation thus avoiding dysfunction and damage. For that, I am studying the neural system of a unique animal model, the Bullfrog, which evolved neural plasticity that allows its neurons to resist severe hypoxia. During my graduate studies (master’s and Ph.D.) I investigated thermoregulation, metabolic and respiratory physiology of birds facing inflammatory processes, oxygen deprivation, and pollutants exposure, and also of lizards during reproductive endothermy. As a postdoctoral associate in Dr. Santin’s lab, I am aiming to describe the mechanisms Bullfrogs use to maintain neuronal performance during oxygen deprivation. Despite the interesting evolutionary input of this research, understanding how this circuit changes itself to resist energetic stress has the potential to uncover mechanisms and design principles that could eventually lead to improved performance of the human brain during hypoxia.

Recent Publications:

Amaral-Silva, L.; Silva, W. C.; Gargaglioni, L. H; Steiner, A.; Bícego, K. C. Metabolic trade-offs favor regulated hypothermia and inhibit fever in immune-challenged chicks. Journal of Experimental Biology. DOI: 10.1242/jeb.243115

Editorial in the Journal of Experimental Biology, volume 225, number 4, February 2022.

Bueschke, N.*; Amaral-Silva, L.*; Adams, S.; Santin, J. M. Transforming a neural circuit to function without oxygen and glucose delivery. Current Biology, DOI: 10.1016/j.cub.2021.11.003. * Authors made equal contributions

Bueschke, N.*; Amaral-Silva L.*; Hu, M., Santin, J. M. Lactate ions induce synaptic plasticity to enhance output from the central respiratory network. The Journal of Physiology, DOI: 10.1113/JP282062. * Authors made equal contributions

Amaral-Silva, L.; Rojas-Antich, M. C.; Dubansky, B.; Tazawa, H. Burggren, W. W. Embryotoxicity and physiological compensation in chicken embryos exposed to crude oil. Environmental Toxicology and Chemistry, Doi: 10.1002/etc.5105.

Amaral-Silva, L.; Gargaglioni, L. H.; Steiner, A. A.; Oliveira, M. T.; Bícego, K. C. Regulated hypothermia in response to endotoxin in birds. The Journal of Physiology. Doi: 10.1113/JP281385. Cover of The Journal of Physiology, volume 599, number 11, 1 June 2021.

Bautista, N. M.; Amaral-Silva, L.; Dzialowski E.; Burggren, W. W. Dietary exposure to low levels of crude oil affects physiological and morphological phenotype in adults and their offspring in the king quail (Coturnix chinensis). Frontiers in Physiology. Doi: 10.3389/fphys.2021.661943.

Amaral-Silva, L.; Burggren, W. W.; Bícego, K. C. Metabolic and Hematological Responses to Endotoxin-Induced Inflammation in Chicks Experiencing Embryonic TCDD Exposure.
Environmental Toxicology and Chemistry, Doi: 10.1002/etc.4832. 2020.

Amaral-Silva, L.; Lambertz, M.; Zara, F. J.; Klein, W.; Gargaglioni, L. H.; Bícego, K. C. Parabronchial remodeling in chicks in response to embryonic hypoxia. Journal of Experimental
Biology, Doi: 10.1242/Jeb.197970. 2019.

Amaral-Silva, L.; Scarpellini, C. S.; Toro-Velasquez, P. A.; Fernandes, M.H.M.R.; Gargaglioni, L. H.; Bícego, K. C. Hypoxia during embryonic development increases energy metabolism in
normoxic juvenile chicks. Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, https://Doi.Org/10.1016/J.Cbpa.2017.03.002. 2017.

Gargaglioni, L.; Amaral-Silva, L.; Da Silva, G. S. F.; Bícego, K. C. Fisiologia do sistema respiratório (Resiratory System Physiology). In: Marcos Macari; Alex Maiorka. (Org.).
Fisiologia das aves comerciais (Commercial Avian Physiology). 1ed. Jaboticabal-SP: FUNEP,
2017, v. 1, p. 74-98.