Chromosome segregation in meiosis, chromosomal proteins, Drosophila genetics.
Ph.D., University of Washington
I am interested in how chromosomes are partitioned into daughter cells upon cell division. My research is currently focused on chromosome segregation in meiosis, using the fruit fly Drosophila melanogaster as a model system. Errors in meiotic chromosome transmission are the single most common source of genetic syndromes in humans, affecting more than 1/500 live births. Studies in models organisms such as yeasts, flies and nematodes have provided us with a variety of clues about the causes of such errors. In my lab, we use molecular, cell and genetic approaches to characterize a collection of mutations that increase the frequency of the meiotic chromosome errors in the male fly. These studies may lead to the identification of genes and/or genetic pathways that are evolutionarily conserved, and may shed light on similar mechanisms that operate in humans.
Matsui M, Sharma K, Cooke C, Wakimoto BT, Rasool M, Hayworth M, Hylton CA, Tomkiel JE. 2011 Sep 6. Nuclear Structure and Chromosome Segregation in Drosophila Male Meiosis Depend on the Ubiquitin Ligase dTopors.Genetics, [Epub ahead of print].
Arya, G.H., M.J. Lodico, O.I. Ahmad, R. Amin, and J.E.Tomkiel, 2006. Molecular Characterization of teflon, a Gene Required for Meiotic Autosome Segregation in Male Drosophila melanogaster. Genetics, 174: 125-134.
Malmanche, N., Owen, S., Gegick, S., Tomkiel, J.E. and C.E. Sunkel, 2007. Drosophila BubR1 is Essential for Meiotic Sister-Chromatid Cohesion and Maintenance of Synaptonemal Complex. Curr. Biol, 17:1489-1497.
Genetics (BIO 392)
Genetics Lab (BIO 393)
Advanced Topics in Genetics: Genetics of Aging (BIO 506)
Epigenetics (BIO 587)