Hongmei Li-Byarlay

Hongmei Li-Byarlay

Postdoctoral Fellow
Dr. Olav Rueppell

(336) 334-5391
206 Eberhart Building


Ph.D., Purdue University


My current focus is the mechanism of stressors (pesticide, migration, or pathogens) in honey bee development, and how different stressors impact genetic and epigenetic architecture of the honey bee at both individual and colony levels.

Recent Publications:

Li-Byarlay H#, Rittschof CC#, Massey JH*, Pittendrigh BR, and Robinson GE. 2014. Socially responsive effects of brain oxidative metabolism on aggression. Proc. Natl. Acad. Sci. USA. 111: 12533–12537.

Wang L, Chi YH, Guo F, Li-Byarlay H, Balfe S, Fang J, Pittendrigh BR, and Zhu-Salzman K. 2014. Transcriptomic response of cowpea bruchid to N-acetylglucosamine-specific lectins. Insect Sci. DOI:10.1111/1744–7917.12108.

Strycharz JP, Lao A, Li H, Qiu X, Lee SH, Sun W, Yoon K S, Doherty JJ, Pittendrigh BR, and Clark, JM. 2013. Resistance in the highly DDT-resistant 91-R strain of Drosophila melanogaster involves decreased penetration, increased metabolism, and direct excretion. Pestic. Biochem. Physiol. 107: 207–217.

Li-Byarlay H, Li Y, Stroud H, Feng S, Newman TC, Kaneda M, Hou K, Wickline SA, Kim C, Worley C, Elsik G, Jacobsen SE, Ma J, and Robinson GE. 2013. RNA interference knockdown of DNA methyl-transferase 3 affects gene alternative splicing in the honeybee. Proc. Natl. Acad. Sci. USA. 110: 12750–12755. (Cover image)

Li Y, Li-Byarlay H, Burns P, Borodovsky M, Robinson GE, and Ma J. 2013. Self-training algorithm for splice junction detection using RNA-seq and its application to honey bee transcriptomes. Nucleic Acid Res. 41: e51.

Li Y, Li H, Burns P, Borodovsky M, Robinson GE, and Ma J. 2012. TrueSight: Self-training algorithm for splice junction detection using RNA-seq. Res. Comput. Mol. Biol., Lect. Notes Comput. Sci. 7262: 163–164.

Qiu X, Sun W, McDonnell CM, Li H, Wu J, Xie J, Muir W, and Pittendrigh BR. 2012. Genome-wide analysis of genes associated with moderate and high DDT resistance in Drosophila melanogaster. Pest Manage. Sci. 69: 930–937.

McDonnell CM, Li H, Berenbaum MR, Schuler MA, and Pittendrigh BR. 2012. Evolutionary toxicogenomics: diversification of the Cyp12d1 and Cyp12d3 genes in Drosophila species. J. Mol. Evol. 74: 281–296.

Sun L, Li H, Seufferheld MJ, Walters KR, Margam V, Jannasch A, Diaz N, Riley CP, Sun W, Li Y**, Muir WM, Xie J, Wu J, Zhang F, Chen J, Barker E, Adamec J, and Pittendrigh BR. 2010. Systems biology reveals pathways involved in cellular response to methamphetamine. PLoS ONE 6: e18215.

Kirkness EF, Haas BJ, Sun W, Braig HR, et al. 2010. Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle. Proc. Natl. Acad. Sci. USA 107: 12168–12173.

Lee SH, Kang JS, Min JS, Yoon KS, Strycharz JP, Johnson R, Mittapalli O, Margam VM, Sun W, Li H, Xie J, Wu J, Kirkness EF, Berenbaum MR, Pittendrigh BR, and Clark JM. 2010. Decreased detoxification genes and genome size make the human body louse an efficient model to study xenobiotic metabolism. Insect Mol. Biol. 19: 599–615.

Li H, Sun L, Mittapalli O, Muir WM, Xie J, Wu J, Schemerhorn BJ, Jannasch A, Chen JY, Zhang F, Adamec J, Murdock LL, and Pittendrigh BR. 2010. Bowman-Birk inhibitor affects pathways associated with energy metabolism in Drosophila melanogaster. Insect Mol. Biol. 19: 303–13.

Li H, Sun L, Mittapalli O, Muir WM, Xie J, Wu J, Schemerhorn BJ, Sun W, Pittendrigh BR, and Murdock LL. 2009. Transcriptional signatures in response to wheat germ agglutinin and starvation in Drosophila melanogaster larval midgut. Insect Mol. Biol. 18: 21–31.

Li H, Buczkowski G, Mittapalli O, Xie J, Wu J, Westerman R, Schemerhorn BJ, Murdock LL, and Pittendrigh BR. 2008. Transcriptomic profiles of Drosophila melanogaster third instar larval midgut and responses to oxidative stress. Insect Mol. Biol. 17: 325–339.

Li H, 2007. Transcriptomic, proteomic and structural analyses of Drosophila melanogaster larval midgut. PhD dissertation, Purdue University Library e-Pubs: AAI3344182.

Li H, Margam V, Muir WM, Murdock LL, and Pittendrigh BR. 2007. Changes in Drosophila melanogaster midgut proteins in response to dietary Bowman-Birk inhibitor. Insect Mol. Biol. 16: 539–549.