Brain Sex Differences
Epigenetic regulation of brain sexual dimorphism
In model organisms, mate selection and mating behaviors are affected by developmental exposure to environmental estrogenic or anti-androgenic chemicals, suggesting that current environmental levels could be affecting organisms and their behaviors in the wild. One of our interests is to understand epigenetic basis of brain sexual dimorphism and environmentally induced sex-specific behaviors. Using Cyp19a1b-GFP medaka, we dissect basic epigenetic landscape of radial glial cells in the brain and study epigenetic and transcriptional alterations in these cells caused by environmental stressors.