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Epstein-Barr virus and organophosphates – A synergistic effect in B cells?
There have been several studies investigating interactions between pesticide exposure (specifically organochlorines, organohalogens, dioxins, and dibenzofurans), non-Hodgkin’s lymphoma, and EBV antibody titres [1-4]. These studies indicate that high concentrations of chemical pesticides can interact with EBV early antigens and thus may increase the risk of development of non-Hodgkin’s lymphoma. As most everyone is infected with EBV and many are exposed to pesticides, the potential interaction between EBV presence and pesticides mandates exploration. Could EBV predispose B cells to become tumorigenic when exposed to pesticides? This may be the case if pesticides also alter cell signaling pathways and cell cycle regulation, akin to what EBV does in cells.
- Hardell, K., et al., Concentrations of organohalogen compounds and titres of antibodies to Epstein-Barr virus antigens and the risk for non-Hodgkin lymphoma. Oncol Rep, 2009. 21(6): p. 1567-76.
- Hardell, E., et al., Case-control study on concentrations of organohalogen compounds and titers of antibodies to Epstein-Barr virus antigens in the etiology of non-Hodgkin lymphoma. Leuk Lymphoma, 2001. 42(4): p. 619-29.
- Hardell, L., et al., Adipose tissue concentrations of dioxins and dibenzofurans, titers of antibodies to Epstein-Barr virus early antigen and the risk for non-Hodgkin lymphoma. Environ Res, 2001. 87(2): p. 99-107.
- Nordstrom, M., et al., Concentrations of organochlorines related to titers to Epstein-Barr virus early antigen IgG as risk factors for hairy cell leukemia. Environ Health Perspect, 2000. 108(5): p. 441-5.
- Miller, K. and Adamson, A. 2020. Organophosphate Exposure Causes Viral and Cellular Dysregulation in B Lymphocytes. In prep.
- Miller, K. and Adamson, A. 2020. Pesticide Exposure Promotes Epstein-Barr Virus-Related Oxidative Stress and Cell Cycle Checkpoint Control Misregulation in B lymphocytes. In prep.