Drosophila as a model system for viral protein function and interactions
We have successfully utilized Drosophila melanogaster as a model system to identify and study viral protein- host protein interactions. We have studied Epstein-Barr virus and Influenza A virus proteins with this system, and identified important cellular mediators (and potential drug targets) of viral infection.
Drosophila model publications:
Adamson, A., N. Wright, and D. LaJeunesse. 2005. Modeling Early Epstein-Barr Viral Infection in Drosophila melanogaster: The BZLF1 Protein. Genetics 171:1125-1135.
Adamson, A., Chohan, K., Kincaid, J., and LaJeunesse D. 2011. A Drosophila Model for Genetic Analysis of Influenza Viral/Host Interactions. Genetics 189: 495-506.
Adamson, A., and LaJeunesse D. 2012. A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System. The Scientific World Journal – Cell Biology Domain 2012:1-9.
Publications stemming from Drosophila work:
Adamson, A. 2013. Identification of an N-acetylglucosaminyltranferase-IV as a modifier of Epstein-Barr virus BZLF1 activity. Open Journal of Genetics 3(1) 1-5.
Kohio, H. and A. Adamson. 2013. Glycolytic Control of Vacuolar-Type ATPase Activity: A Mechanism to Regulate Influenza Viral Infection. Virology 444: 301-309.
Adamson, A., B. Le, and B. Siedenburg. 2014. Inhibition of mTOR inhibits lytic replication of Epstein-Barr virus in a cell-type specific manner. Virology Journal 11:110.