<em>Drosophila</em> as a model system for viral protein function and interactions

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Drosophila as a model system for viral protein function and interactions

We have successfully utilized Drosophila melanogaster as a model system to identify and study viral protein- host protein interactions.  We have studied Epstein-Barr virus and Influenza A virus proteins with this system, and identified important cellular mediators (and potential drug targets) of viral infection.

Drosophila model publications:

  • Adamson, A., N. Wright, and D. LaJeunesse. 2005. Modeling Early Epstein-Barr Viral Infection in Drosophila melanogaster: The BZLF1 Protein. Genetics 171:1125-1135.
  • Adamson, A., Chohan, K., Kincaid, J., and LaJeunesse D. 2011.  A Drosophila Model for Genetic Analysis of Influenza Viral/Host Interactions.  Genetics 189: 495-506.
  • Adamson, A., and LaJeunesse D.  2012. A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System. The Scientific World Journal – Cell Biology Domain 2012:1-9.

Publications stemming from Drosophila work:

  • Adamson, A. 2005. Epstein-Barr virus BZLF1 protein binds to mitotic chromosomes. Journal of Virology 79:7899-7904.
  • Adamson, A. 2013. Identification of an N-acetylglucosaminyltranferase-IV as a modifier of Epstein-Barr virus BZLF1 activity. Open Journal of Genetics 3(1) 1-5.
  • Kohio, H. and A. Adamson. 2013. Glycolytic Control of Vacuolar-Type ATPase Activity: A Mechanism to Regulate Influenza Viral Infection. Virology 444: 301-309.
  • Adamson, A., B. Le, and B. Siedenburg. 2014. Inhibition of mTOR inhibits lytic replication of Epstein-Barr virus in a cell-type specific manner. Virology Journal 11:110.
  • Adamson, A. 2020. Knockdown of the V1A subunit of the vacuolar V1V0-ATPase protein pump reduces infection by Influenza A virus in a glucose dependent manner.  Under review.
  • Adamson, A., Jeffus, D., Davis, A., and Greengrove, E. 2021. Epstein-Barr virus lytic replication activates and is dependent upon MAPK-interacting kinase 1/2 in a cell-type dependent manner. Under review.

More ongoing!