Zhenquan Jia, Assistant Professor | UNCG Biology

Zhenquan Jia, Assistant Professor

Zhenquan JiaResearch:

My research at UNCG is investigating the environmental toxicant-induced cardiovascular inflammation and neuronal injury with a special interest on determining the underlying signaling mechanisms. In line with this research, my lab is also actively studying the pharmacological agents/novel bioactive compounds that target and reduce toxin-mediated pathogenesis. My approaches include cell- and molecular biology techniques, and different animal models. In a NIH funded project, we are investigating the molecular mechanisms involved in the protective action of flavonoid genistein against proinflammatory cytokine TNF-alpha-induced vascular dysfunction. Based on our hypothesis driven research, we attempt to investigate if genistein acts through cAMP/PKA/ NFκB pathway.

Recent Publications:

Chiu NH, Jia Z, Diaz R, Wright P. Rapid Differentiation of In Vitro Cellular Responses to Toxic Chemicals by Using MALDI-TOF Mass Spectrometry. Environmental Toxicology and Chemistry, 34(1):161-6, 2015.

Li JZ, Ke Y, Misra HP, Trush MA, L YR, Zhu H, Jia Z. Mechanistic Studies of Cancer Cell Mitochondria- and NQO1-mediated Redox Activation of Beta-Lapachone, a Potentially Novel Anticancer Agent. Toxicology and Applied Pharmacology, 29;281(3):285-293, 2014.

Li YR , Zhu H, Kauffman M , Danelisen I, Misra HP, Ke Y, Jia Z. Paraoxonases Function as Unique Protectors against Cardiovascular Diseases and Diabetes: Updated Experimental and Clinical Data. Exp Biol Med, 5;239(8):899-906, 2014.

Nallasamy P, Si H, Babu PV, Fu Y, Brooke BS, Halley S, Zhen W, Zhu H, Liu D, Li Y, Jia Z. Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway. J Nutr Biochem, 25(8):824-33, 2014.

Wright PC, Qin H, Choi MMF, Chiu NH, Jia Z. Carbon nanodots interference with lactate dehydrogenase assay in human monocyte THP-1 cells. SpringerPlus, 3:615:1-5, 2014.

Shah H, Saunders C, Speen A, Brooke E, Nallasamy P, Zhu H, Li and Jia Z. Protection of HepG2 Cells from Acrolein Toxicity by CDDO-Im Via Glutathione-Mediated Mechanism. Exp Biol Med, in press (PMID: 25504014), 2015.

Fu Y, Luo J, Jia Z, Zhen W, Zhou K, Gilbert E, Liu D. Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice. Int J Endocrinol, 2014:846742, 2014.

Jia Z, Velayutham P, Babu A, Si H, Nallasamy P, Zhu H, Zhen W, Misra HP, Li Y, Liu D. Genistein inhibits TNF-α-induced endothelial inflammation through the protein kinase pathway A and improves vascular inflammation in C57BL/6 mice. Int J Cardiol, 3;168(3):2637-45, 2013.

Macrea, M., Martin, T., Zagrean, L., Jia, Z., & Misra, H. Role of leptin as antioxidant in obstructive sleep apnea: an in vitro study using electron paramagnetic resonance method. Sleep Breath, Mar;17(1):105-10, 2013.

Jia Z, Zhen, W, Babu, PV, Liu, D. Phytoestrogen genistein protects against endothelial barrier dysfunction in vascular endothelial cells through PKA-mediated suppression of RhoA signaling. Endocrinology, 154(2):727-37, 2013.

Macrea MM, Martin T, Jia Z, Misra, HP. Leptin's activity on the hydroxyl radical: a possible link to the oxidative stress-related endothelial vasodilation in patients with obstructive sleep apnea. Lung, 191:391–395, 2013.

Graham PM, Li JZ, Dou X, Zhu H, Misra HP, Jia Z, Li Y. Protection against peroxynitrite-induced DNA damage by mesalamine: implications for anti-inflammation and anti-cancer activity. Mol Cell Biochem, 378(1-2):291-8, 2013.

Jia Z, Zhu H., Li J., Wang X., Misra H., Y Li. Oxidative stress in spinal cord injury and antioxidant-based intervention. Spinal Cord, 50 (4), 264-74, 2012.

Sun X, Jia Z. A brief review of biomarkers for preventing and treating cardiovascular diseases. J Cardiovasc Dis Res, 3 (4),251-254, 2012.

Zhu, H., Jia, Z., Misra, H., & Li, Y. Oxidative stress and redox signaling mechanisms of alcoholic liver disease: updated experimental and clinical evidence. J Dig Dis, 13 (3), 133-42, 2012.

Vandjelovic, N., Zhu, H., Misra, H., Zimmerman, R., Jia Z., Y Li. EPR studies on hydroxyl radical-scavenging activities of pravastatin and fluvastatin. Mol Cell Biochem, 364 (1-2), 71-7, 2012.

Si H, Fu Z, Babu PV, Zhen W, Leroith T, Meaney MP, Voelker KA, Jia Z, Grange RW, Liu D. Dietary epicatechin promotes survival of obese diabetic mice and Drosophila melanogaster. J Nutr. 141(6):1095-100, 2011.

Zimmerman RP, Jia Z, Zhu H, Vandjelovic N, Misra HP, Wang J, Li Y. Induction of Oxidative DNA Damage by Mesalamine in the Presence of Copper: A Potential Mechanism for Mesalamine Anticancer Activity. Toxicology 27; 280(3):71-6, 2011.


Essentials of Toxicology (BIO 488)
Environmental Health Science II (Bio 632)
Molecular Toxicology (Bio 635)


321 Sullivan Science Building
(336) 256-0078